Macrophages and age-dependent resistance to hepatitis induced by herpes simplex virus type 2 im mice
- 1 January 1978
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 19 (1), 46-50
- https://doi.org/10.1128/iai.19.1.46-50.1978
Abstract
An age-dependent increase in the resistance of BALB/c mice to induction of focal necrotic hepatitis by herpes simplex virus type 2 was demonstrated. In 3 wk old mice inoculated i.p. with virus, numerous necrotic foci developed in the liver. As the mice matured, the number of lesions declined until the age of 8 wk, when no further increase in resistance appeared. Corresponding to this, the virus titers of livers and spleens of 3 wk old mice were higher than in 8 wk old animals throughout the infection, and the infection was apparently terminated in these organs of the adult mice by day 5. In vitro infection of peritoneal macrophages from 3 wk old and 8 wk old mice showed that this age-related resistance was concomitant with an increased restriction of virus replication in peritoneal macrophages from adult mice. Since the resistance of adult mice could be abolished by i.v. inoculation of the macrophage-toxic agent silica before infection, and since adoptive transfer of 2 .times. 106 syngeneic macrophages from adult mice to young ones conferred to the latter a resistance comparable to that of the adult mice, macrophage maturation is apparently responsible for the age-dependent resistance seen in this infection.This publication has 18 references indexed in Scilit:
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