A COMPARISON OF THE CREATININE AND UREA CLEARANCE TESTS OF KIDNEY FUNCTION

Abstract

The creatinine and urea clearance tests have been compared in normal persons and in patients with Bright''s disease. The mean creatinine clearance in 130 observations of 59 normal subjects was 148 cc. per min. The variability of the two tests from the mean normal was approximately the same in our hands. In patients with Bright''s disease the creatinine and urea clearance tests are generally equally reduced in relation to the average normal. The creatinine test was not found to have any practical advantage to compensate for the greater technical difficulty.