Simultaneous liquid-chromatographic determination of carbamazepine and its epoxide metabolite in plasma.
- 1 October 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 28 (10), 2127-2130
- https://doi.org/10.1093/clinchem/28.10.2127
Abstract
We describe a liquid-chromatographic method for the simultaneous quantification of carbamazepine and its 10,11-epoxide metabolite in plasma. The method is used routinely in the analysis of carbamazepine and its epoxide in 0.5 mL of plasma at concentrations of 1 to 20 and 0.2 to 5 mg/L, respectively. The use of peak-height ratios as a measure of detector response appeared to provide better precision and accuracy than peak-area ratios.This publication has 5 references indexed in Scilit:
- Simultaneous liquid chromatographic analysis for carbamazepine and carbamazepine 10,11-epoxide in plasma and saliva by use of double internal standardizationJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Further observations on carbamazepine plasma levels in epileptic patientsNeurology, 1976
- Determination of carbamazepine in blood or plasma by high-pressure liquid chromatography.Clinical Chemistry, 1976
- A Comparative Controlled Study Between Carbamazepine and Diphenylhydantoin in Psychomotor EpilepsyEpilepsia, 1976
- Kinetics of carbamazepine and its 10,11‐epoxide metabolite in childrenClinical Pharmacology & Therapeutics, 1976