I. THE EFFECT OF THE PARATHYROID HORMONE ON GASTRIC SECRETION

Abstract

Because overdosage of the dog with parathyroid hormone causes bleeding into the fundic region of the stomach, the influence of the hormone on gastric secretion was tested. The normal secretory responses of 4 Pavlov-pouch dogs to single injections of small amounts of histamine dihydrochloride were first determined in terms of volume and acidity of collected juice. The animals were then injected with parathormone and the responses to histamine dihydrochloride again determined in the same manner on the hypercalcemic animals. In both control and experimental periods the Ca content of the blood and gastric juice was estimated. The results indicated that, if the degree of dehydration is controlled, the moderate overdosage with parathormone has no effect on gastric secretion or Ca content of the juice, which was 5-6.5 mgm. of Ca per 100 cc. On the other hand, extreme overdosage to an extent to cause hemorrhage or great dehydration resulted in decreased secretory responses without greatly affecting the Ca content of the gastric juice.