Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide
- 22 December 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (2), 311-314
- https://doi.org/10.1021/ol047686a
Abstract
The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule-stabilizing agent (+)-discodermolide (1) have been achieved. Structure−activity relationships of the C(19) carbamate were defined, exploiting two synthetically simplified scaffolds, as well as the parent (+)-discodermolide framework.Keywords
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