Kernicterus in Rats Lacking Glucuronyl Transferase

Abstract

In previous papers,^20,5,55 we have described the occurrence of kernicterus in the Gunn strain of rats, as well as some of the factors which influence its incidence and pathogenesis. This paper concludes our current study of the rats and summarizes approximately 2 years of observation. Methods and Terminology As in the previous papers, the jaundice gene is designated by the small letter j and the normal gene by the capital letter J.⁵⁵ Kernicterus is defined as previously⁵⁵ and is abbreviated in tables as KI. The methods for serum bilirubin (S.B.) and sulfonamide determinations have been previously described.⁵⁵ Sodium p-aminohippurate (Na PAH) determinations were done by a micromodification of the method of Smith.⁹⁴ Sodium glucuronate (Na GA) was determined by a micromodification of the method of Fishman.²⁹ Total protein (T.P.) determinations were done on 20Λ of serum by an unpublished modification of the biuret