Psoriasis Bench to Bedside
- 1 April 2009
- journal article
- editorial
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 145 (4), 462-464
- https://doi.org/10.1001/archdermatol.2009.73
Abstract
More than 25 years of accumulating evidence strongly implicates the immune system in the pathogenesis of psoriasis, including both acquired immunity (T cells) and innate host defense (macrophages, antigen-presenting cells, and keratinocytes). Psoriasis also has a strong genetic component, but the identity of the genes involved has largely remained obscure. In a study recently published in Nature Genetics,1 these 2 themes of psoriasis—genetics and immunology—come together in a coherent and clinically relevant way.Keywords
This publication has 28 references indexed in Scilit:
- Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasisNature Genetics, 2009
- Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathwaysNature Genetics, 2009
- Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosusNature Genetics, 2008
- A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease LociPLoS Genetics, 2008
- Psoriasis is associated with increased β-defensin genomic copy numberNature Genetics, 2007
- Two independent alleles at 6q23 associated with risk of rheumatoid arthritisNature Genetics, 2007
- TH-17 cells in the circle of immunity and autoimmunityNature Immunology, 2007
- A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk GenesAmerican Journal of Human Genetics, 2007
- Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 GeneAmerican Journal of Human Genetics, 2006
- A haplotype map of the human genomeNature, 2005