One hundred forty-seven cases of clinically localized Hodgkin's disease, admitted between 1947 and 1963, are reviewed. The incidence of local control by intensive regional radiotherapy was analyzed in terms of tumor dose, overall treatment time, and therapy techniques for the major areas of clinical involvement. Although overall survival figures for Stages I and II were similar to other recorded results, statistically significant differences became apparent when the material was analyzed by clinical presentation, specific histology, constitutional symptomatology, and from survival and relative incidence of first manifestations of new disease. Significance of these observations is considered.