Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs
- 16 June 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4910), 1360-1362
- https://doi.org/10.1126/science.2660263
Abstract
Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from their ability to antagonize the excitotoxic actions of endogenous excitatory amino acids such as glutamate and aspartate. There is growing interest in the potential application of these compounds in the treatment of neurological disorders. However, there is an apparent neurotoxic effect of PCP and related agents (MK-801, tiletamine, and ketamine), which has heretofore been overlooked: these drugs induce acute pathomorphological changes in specific populations of brain neurons when administered subcutaneously to adult rats in relatively low doses. These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.This publication has 21 references indexed in Scilit:
- MK-801 powerfully protects against N-methyl aspartate neurotoxicityEuropean Journal of Pharmacology, 1987
- MK-801 protects the neonatal brain from hypoxic-ischemic damageEuropean Journal of Pharmacology, 1987
- Non-competitive antagonists of excitatory amino acid receptorsTrends in Neurosciences, 1987
- Autoradiographic distribution of phencyclidine receptors in the rat brain using [3H]1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP)Neuroscience Letters, 1986
- High correlation between the localization of [3H]TCP binding and NMDA receptorsEuropean Journal of Pharmacology, 1986
- Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 1984
- Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated RatsScience, 1983
- Pain insensitivity in psychosisAnnals of Emergency Medicine, 1982
- Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the catEuropean Journal of Pharmacology, 1982
- PhencyclidineNature, 1980