Insulin Secretion in Obesity

Abstract

ALTHOUGH hyperinsulinemia has been well established in obese subjects^{1 , 2} only some demonstrate abnormalities of glucose tolerance. It has been suggested that the ability of the obese subject to maintain normal glucose tolerance is a function of B-cell reserve, implying that insulin secretory rates and plasma insulin levels would be higher in obese subjects with normal glucose tolerance than in those with abnormal glucose tolerance. However, if obese subjects with abnormal glucose tolerance were demonstrated to have higher insulin levels than those with normal glucose tolerance, insulin resistance would be a more suitable explanation.This investigation was undertaken to study the . . .