Properties of rotational behaviour produced by methylxanthine derivatives in mice with unilateral striatal 6-hydroxydopamine-induced lesions.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 4 (4), 301-307
- https://doi.org/10.1248/bpb1978.4.301
Abstract
The present investigation was undertaken to study effects of methylxanthine derivatives on rotational behavior produced by dopamine receptor stimulating drugs and properties of methylxanthine-induced rotation in mice with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the striatum. L-Dopa 10 mg/kg, i.p., produced contralateral turning which lasted for .apprx. 40 min. When L-dopa 10 mg/kg was given to mice in combination with theophylline 25 mg/kg, total turns for 2 h were significantly higher than those of L-dopa and theophylline dose. Caffeine and theophylline in doses of 25 and 50 mg/kg, i.p., respectively, produced marked increase in contralateral rotation in a dose-dependent manner in mice with lesions. Theobromine 100 mg/kg, i.p., also produced a moderate contralateral rotation. Total turns of ipsilateral rotation produced by methylxanthine derivatives were < 10% of those of contralateral circling. Theophylline-induced contralateral rotation was reduced to nearly 30% of the control by .alpha.-methyl-p-tyrosine (.alpha.-MPT). It was suppressed by spiroperiodol, at a dose higher than that to apomorphine or methamphetamine. Methylxanthine derivatives produce contralateral rotational behavior due to not only phosphodiesterase inhibition but dopamine receptor stimulation.This publication has 10 references indexed in Scilit:
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