The Histogenesis of Retinoblastoma

Abstract

The histogenesis of human retinoblastoma has long been a constantly debatable problem since the last century. Rosettes of retinoblastoma were studied by EM using 15 eyes as specimens. The evidences suggest that the rosette is composed of visual cells and glial (possibly Mueller) cells, providing characteristics of the primitive retina. Retinoblastoma does not arise from either of the developing neuronal or glial cells, but from the multipotential embryonic retinal cell which is capable of being differentiated into either of these 2 cellular systems.