Aromatase Inhibitors III. Studies on the Antifertility Effect of 4-Acetoxy-4-androstene-3,17-dione1, 2, 3
- 1 April 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 18 (3), 365-370
- https://doi.org/10.1095/biolreprod18.3.365
Abstract
4-Acetoxy-4-androstene-3,17-dione (4-acetoxy-A) was demonstrated to be an effective aromatase (estrogen synthetase) inhibitor in vitro. To study the effect of the compound on estrogen-dependent processes, rats were treated with silastic wafers containing 4-acetoxy-A (75 mg). These were inserted under the skin on Day 1 of diestrus. When housed continuously with male rats from the expected day of proestrus, 7/8 rats did not mate after 6-15 days of cohabitation.This publication has 6 references indexed in Scilit:
- The effects of an inhibitor of aromatization (1,4,6-androstatriene-3,17-dione) and an anti-estrogen (Cl-628) on in vivo formed testosterone metabolites recovered from neonatal rat brain tissues and purified cell nuclei. Implications for sexual differentiation of the rat brainBrain Research, 1977
- The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer11Endocrinology, 1977
- Studies on the mechanism of estrogen biosynthesis in the rat ovary–IThe Journal of Steroid Biochemistry and Molecular Biology, 1976
- Blockade of Testosterone-Induced Mounting Behavior in the Male Rat with Intracranial Application of the Aromatization Inhibitor, Androst-l,4,6-triene-3,17-dioneEndocrinology, 1975
- Effects of a Single Injection of an Estrogen Antagonist on the Estrous Cycle of the Rat1Endocrinology, 1968
- EXPERIMENTAL STUDIES ON THE EFFECTS OF OVARIECTOMY AND HYPOPHYSECTOMY ON BLASTOCYST IMPLANTATION IN THE RATActa Endocrinologica, 1963