Influence of Chlorpromazine and Cortisone on Protein Metabolism of Rats

Abstract

Chlorpromazine at dose level of 3.4 mg daily causes an increase of urinary N excretion and a decrease of weight gain in the intact tube fed rat. These changes are statistically significant. The protein catabolic effect of 5 mg of cortisone acetate given daily is increased significantly by simultaneous treatment with chlorpromazine.