The effects of acute ethanol feeding and of chronic benfluorex administration on the activities of some enzymes of glycerolipid synthesis in rat liver and adipose tissue

Abstract

Rats were treated for 5 days with benefluorex {1-(3-trifluoromethylphenyl)-2-[N-(2-benzoyloxyethyl)amino]propane} or with suspending medium (controls). They were then intubated with an acute intoxicating dose of ethanol or with glucose of equivalent energy content. Treatment of the control rats with ethanol specifically increases the hepatic activity of the soluble phosphatidate phosphohydrolase by about 5-fold in 6h. The equivalent increase for the benfluorex-treated rats were about 2-fold. Results are discussed in relation to effects of ethanol and benfluorex on glycerolipid synthesis.