Studies on Fibrinolysis: I. A Circulating Substance Capable of Converting Plasmin-Sensitive to Plasmin-Resistant Clots.

Abstract

Summary and conclusions In vitro resistance to fibrinolysis was produced by incubation of thrombin-fibrinogen clots in either serum, plasma, barium sulfate adsorbed plasma or the globulin fraction of serum. The activity responsible for clot-resistance to fibrinolysis was non-dialyzable, destroyed by acidification or heat, and distinguishable from serum antiplasmin. Tht data presented suggest that the above effect is mediated by a change in the clot itself rather than an alteration in fibrinolytic mechanism.