Anaphylaxis following Administration of Tetanus Toxoid

Abstract

Two cases of anaphylactic shock following the administration of a 2d dose of tetanus toxoid are descr. The incidence of general and local reaction following the subcut. inoculation of 61,042 healthy individuals with tetanus toxoid, using two 1-cc. doses at a 6-weeks interval is reviewed. Anaphylactic reactions occurred in 0.003% of cases, less severe, constitutional symptoms in 0.02%, and local reactions in 1.06%. Though the incidence of general reaction after tetanus toxoid is rare, it is advisable to be prepared to treat it expeditiously with adrenaline hydrochloride when it does occur.