Hormonal regulation of phosphorylase phosphatase activity in rat liver
Open Access
- 28 July 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 203 (2), 253-256
- https://doi.org/10.1016/0014-5793(86)80753-0
Abstract
The effect of glucagon and insulin on rat liver phosphorylase phosphatase activity in vivo was investigated. The activity of phosphatase was found to decrease following the administration of glucagon and increase with insulin in a reversible manner. No change was detected in the activity of heat‐stable phosphatase inhibitors in the hormone‐treated samples. Liver protein kinases (regulatory subunit of cAMP‐dependent protein kinase and/or Ca2+ ‐dependent phosphorylase kinase) are suggested to regulate the activity of hepatic phosphorylase phosphatase (type 1 and 2A).Keywords
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