Comparative pharmacokinetics of cefamandole, cefuroxime and cephradine during total hip replacement
- 1 May 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 17 (5), 637-640
- https://doi.org/10.1093/jac/17.5.637
Abstract
Serum, bone and tissue levels of the three cephalosporins, cefamandole, cefuroxime and cephradine were determined in 60 patients given a single 1 g dose intravenously before total hip surgery and two similar doses at 8 h intervals. The levels achieved were comparable for all three antibiotics, hence the choice of prophylactic antibiotic for total hip replacement should be guided by the pathogens causing infection and cost of the antibiotic.Keywords
This publication has 2 references indexed in Scilit:
- Bone concentrations of cefuroxime and cefamandole in the femoral head in 96 patients undergoing total hip replacement surgeryJournal of Antimicrobial Chemotherapy, 1982
- The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacementJournal of Bone and Joint Surgery, 1977