FUNCTIONAL ABNORMALITIES OF NEUTROPHILS IN CANCER-PATIENTS - INEFFICIENT PHAGOCYTOSIS AND REVERSE ENDOCYTOSIS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 27 (7), 261-266
Abstract
A study of neutrophil functions was performed in 17 patients with advanced cancer and 21 controls. Their phagocytic activity, index of reduction of NBT [nitroblue tetrazolium] and their myeloperoxidase activity were examined. Cancer patients might have a factor or factors in their plasma which interfere (s) with phagocytosis and which promote (s) exocytosis of lysosomal enzymes (reverse endocytosis) from autologous polymorphonuclear leukocytes as well as cells obtained from normal healthy donors.