Coupling of Amino Acids and Amino Sugars with Cyanuric Chloride (2,4,6-Trichloro-s-triazine)

Abstract

2,4,6-Trichloro-s-triazine (cyanuric chloride) has been used to couple glycine ethyl ester with seven carbohydrate derivatives that contain amino groups. The reactions proceed in high yield under mild conditions. The compounds serve as models for the coupling of carbohydrates to proteins by well-defined linkages through amino groups.