Placental Enzyme Polymorphisms in Canadian Populations

Abstract

Phenotype distributions and allele frequencies of phosphoglucomutase loci PGM1, PGM2, and PGM3 were determined for 4 Canadian populations: SWO-Random, a randomly chosen group from southwestern Ontario; SWO-Caucasian, selected from SWO; Indian and Eskimo from the James and Hudson area. In the 2 population samples from southwestern Ontario, allele frequencies were similar to those of European populations but there was a marked excess of homozygotes at the PGM1 locus. In Indians the .**GRAPHIC**. allele had a frequency of 0.922, that of the .**GRAPHIC**. allele was 0.765. The allele frequencies for the Eskimo population were 0.848 for .**GRAPHIC**. and 0.884 for .**GRAPHIC**. One rare phenotype was found at each of the PGM1 and PGM2 loci.