Pattern of Adaptive Control of Levels of Rat Liver Tryptophan Transaminase
- 19 June 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 129 (3364), 1672-1673
- https://doi.org/10.1126/science.129.3364.1672
Abstract
The dual control by substrate and hormone of the level of a third adaptive enzyme in animals is described. Injections of hydrocortisone or the substrate tryptophan increased the level of the liver tryptophan-α-ketoglutarate transaminase of intact rats within 5 hours. In adrenalectomized rats this enzyme level was increased by hydrocortisone alone, but substrate induction could be demonstrated only if these animals were treated at the same time with hydrocortisone.Keywords
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