Phorbol esters stimulate a phospholipase D‐catalysed reaction with both ester‐ and ether‐linked phospholipids in HeLa cells
- 23 October 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 257 (1), 35-37
- https://doi.org/10.1016/0014-5793(89)81779-x
Abstract
The phorbol ester, 12-tetradecanoylphorbol-13-acetate (TPA), stimulated the accumulation of labelled phosphatidylethanol (PEth) in HeLa cells prelabelled with [3H]hexadecanol and incubated in the presence of ethanol. PEth formation involves a phospholipase D-catalysed phosphatidyl transferase reaction. [3H]Hexadecanol labelled both ester- and ether-derivatives of HeLa cell phospholipids and TPA stimulated the conversion of both classes of lipid to PEth.Phorbol ester; Phospholipase D; Ether phospholipiKeywords
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