Mitigated Teratogenicity of Thio-TEPA in Goldthioglucose Obese Mice.

Abstract

Summary Teratogemcity of 3 mg/kg of triethylene thiophosphoramide (thio-TEPA), given intraperitoneally on day 10 of gestation, was examined in obese and non-obese mice. Obesity was induced with goldthioglu-cose (GTP). No difference was observed in fetal mortality, but frequency of fetuses with‘malformations caused by thio-TEPA was reduced in the obese mothers. Live fetuses in the obese group showed slight growth retardation.