Dopaminergic neuronal responses to a non-amphetamine CNS stimulant
- 1 March 1979
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 44 (1-2), 39-49
- https://doi.org/10.1007/bf01252700
Abstract
The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid—DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition withα-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.This publication has 26 references indexed in Scilit:
- Localization of Nigral Dopamine-Sensitive Adenylate Cyclase on Neurons Originating from the Corpus StriatumScience, 1977
- The substantia nigra of the rat: A golgi studyJournal of Comparative Neurology, 1977
- Dopamine-Sensitive Adenylate Cyclase: Location in Substantia NigraScience, 1977
- Self-inhibition by dopaminergic neurones: Disruption by (±)-α-methyl-p-tyrosine pretreatment or anterior diencephalic lesionsNeuropharmacology, 1976
- Actions of amfonelic acid and other non-amphetamine stimulants on the dopamine neuronJournal of Pharmacy and Pharmacology, 1976
- d -Amphetamine-Induced Inhibition of Central Dopaminergic Neurons: Mediation by a Striato-Nigral Feedback PathwayScience, 1976
- Central dopaminergic neurons: Effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acidEuropean Journal of Pharmacology, 1976
- Amphetamine psychosis: Behavioral and biochemical aspectsJournal of Psychiatric Research, 1974
- The effect of some psychoactive drugs on central monoamine neuronsEuropean Journal of Pharmacology, 1967
- Precise Localization of Renshaw Cells with a New Marking TechniqueNature, 1965