Destruction of Enteroviral Ribonucleic Acid Infectivity by Phosphodiesterase.

Abstract

Summary Infectivity of RNA from ECHO 7 and 12 and Coxsackie A9 viruses was destroyed by snake venom phosphodiesterase (SVP) whereas the infectivity of the corresponding intact viruses was unaffected by this enzyme. At 25° using ECHO 7 RNA and 2 μg SVP per ml, rate of inactivation was constant through approximately 20 minutes, then progressively decreased.