Inhibition of Growth of Leukemia Cells by Enzymic Folate Depletion
- 9 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3979), 161-162
- https://doi.org/10.1126/science.172.3979.161
Abstract
A new bacterial enzyme, designated as carboxypeptidase G1, inhibited growth of the L5178Y and L1210 murine leukemias, as well as the Walker carcinoma and the human lymphoblastoid line (RPMI 4265), propogated in vitro. This enzyme hydrolyzes the glutamate moiety from both oxidized and reduced folate forms, and thus it may prove to be of value in creating rapid folate depletion in vivo.Keywords
This publication has 3 references indexed in Scilit:
- L-AsparaginaseAnnual Review of Medicine, 1970
- The Enzymatic Hydrolysis of Methotrexate and Folic AcidJournal of Biological Chemistry, 1967
- The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in CultureJournal of Biological Chemistry, 1959