The acute effect of sertindole on brain 5-HT2, D2 and ?1 receptors (ex vivo radioreceptor binding studies)

Abstract

The ability of sertindole to influence the ex vivo binding of³H-ketanserin,³H-prazosin and³H-spiperone to 5-HT₂ receptors, α₁-adrenoceptors and DA D₂ receptors, respectively, in rat brain has been studied after acute treatment. Sertindole is a potent, long acting compound which readily passes the blood-brain barrier. It dose-dependently binds to all three receptors types. In line with in vivo behavioural experiments sertindole has the most pronounced effect on 5-HT₂ receptors, lower effect on α₁-adrenoceptors and the lowest effect on striatal D₂ receptors.