Mild and Efficient Conversion of Nitriles to Amides with Basic Urea-Hydrogen Peroxide Adduct
- 1 December 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (22), 3149-3155
- https://doi.org/10.1080/00397919308011173
Abstract
The urea-hydrogen peroxide adduct, an inexpensive, stable and easily handled reagent has shown utility for mild and efficient transformation of nitriles into the corresponding aliphatic or aromatic amides. Reaction proceeds in aqueous acetone, within 0.5-2.5h, in the presence of catalytic amount of K2CO3, at room temperature.Keywords
This publication has 28 references indexed in Scilit:
- The Transformation of Nitriles into Amides Using Sodium PercarbonateSynthetic Communications, 1990
- A Mild and Convenient Oxidation of Aryl Nitriles to Aryl Amides by Aqueous Sodium PerborateSynthetic Communications, 1990
- Catalytic Hydration of Nitriles to Amides with Manganese Dioxide on Silica GelSynthesis, 1988
- A New Method for the Preparation of Amides from Nitriles by use of HydroxylaminesSynthesis, 1984
- Facile Hydration of Nitriles to Amides Using Potassium Fluoride on AluminaSynthetic Communications, 1982
- Mechanism of the Reaction of Nitriles with Alkaline Hydrogen Peroxide. Reactivity of Peroxycarboximidic Acid and Application to Superoxide Ion ReactionBulletin of the Chemical Society of Japan, 1981
- A simple method for converting nitriles to amides. Hydrolysis with potassium hydroxide in tert-butyl alcoholThe Journal of Organic Chemistry, 1976
- The mild selective conversion of nitriles to amidesTetrahedron Letters, 1974
- THE TRANSFORMATION OF NITRILES INTO AMIDES BY THE USE OF TiCl4Chemistry Letters, 1973
- Ueber die Oxydation mittelst WasserstoffsuperoxydsEuropean Journal of Inorganic Chemistry, 1884