AIDS-Antiviral Sulfolipids From Cyanobacteria (Blue-Green Algae)
- 16 August 1989
- journal article
- editorial
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 81 (16), 1254-1258
- https://doi.org/10.1093/jnci/81.16.1254
Abstract
A recently developed tetrazolium-based microculture assay was used to screen extracts of cultured cyanobacteria (blue-green algae) for inhibition of the cytopathic effects of the human immunodeficiency virus (HIV-1), which is implicated as a causative agent of AIDS. A number of extracts were found to be remarkably active against the AIDS virus. A new class of HIV-1-inhibitory compounds, the sulfonic acid-containing glycolipids, was discovered through the use of the microculture assay to guide the fractionation and purification process. The pure compounds were active against HIV-1 in cultured human lymphoblastoid CEM, MT-2, LDV-7, and C3-44 cell lines in the tetrazolium assay as well as in p24 viral protein and syncytium formation assays. [J Natl Cancer Inst 81:1254–1258, 1989]This publication has 6 references indexed in Scilit:
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