Cerebral Gigantism

Abstract
Four cases of cerebral gigantism are reported, and their historical, phys ical and investigative findings are compared with those of other re ported cases. The triad of a period of rapid growth, advanced bone age and absence of precocious sexual development is characteristic of this syndrome and is seen rarely in other conditions. Extensive growth hormone and other pertinent assays, including circadian studies, failed to demonstrate any excess of endocrine secretions.