HETEROGENEITY OF STEM-CELLS IN SEVERE COMBINED IMMUNODEFICIENCY
- 1 January 1976
- journal article
- research article
- Vol. 25 (3), 462-471
Abstract
Two patients with severe combined immunodeficiency disease (SCID) having variable B[bone marrow-derived]-cell development have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T[thymus-derived]-cell surface characteristics (HTLA+ [human T lymphocyte antigenicity] phenotypes). Their marrow cells could not be induced by these same factors to develop the E[sheep erythrocyte]-rosette marker or functional activities of T lymphocytes. The marrow of these children also showed, when compared to that of normal adults, a different distribution of cellular elements on density gradient fractionation. This disorder probably has a different pathogenesis from other forms of SCID previously analyzed.This publication has 25 references indexed in Scilit:
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