Discussions of various religions in current revisions of the Bible should be of interest to dermatologists, for these discussions include reviews of the biblical concept of leprosy. Unfortunately, terms now suggested as substitutes for "leprosy," often considered in the Bible as a moral sin, include "affections of the skin" and even "psoriasis." The background of this ancient controversy is presented as regards the significance of white spots, the influences of ancient Greek medicine, current plans of some religions, and recommendations.