EFFECTS OF DORSAL ROOT SECTION ON CHOLINE ESTERASE CONCENTRATION IN SPINAL CORD OF CATS

Abstract
Detns. of the conc. of choline esterase in the grey matter of the 6th lumbar segment of the spinal cord in cats yield avg. QChE values in normal animals of 13.7 and 13.9 in the left and right dorsal quadrant wedges and 17.6 and 18.6 in the left and right ventral quadrant wedges. After unilateral deafferentation at the level of the 3rd to 7th lumbar segments, a decrease of QChE of about 10 to 20% was observed in all four quadrant wedges. After bilateral deafferentation, the % decrease was approx. twice as great, i.e., about 30% in all 4 quadrant wedges. Nervous degeneration thus results in diminution of choline esterase activity not only in muscle and sympathetic ganglia (as has previously been shown) but also in the C. N. S.