Rickets, the Continuing Challenge

Abstract

Appropriate environmental measures and the wide use of vitamin D have led to the nearly complete disappearance of common rickets in most developed countries (with the exception of those few that have yet to begin fortifying milk). In other parts of the world, however, rickets remains a public health problem. In addition, there are acquired and heritable forms of rickets that develop despite adequate availability of vitamin D. Precise diagnosis and management of these forms have improved considerably over the past two decades.Strictly speaking, rickets is caused by any interference with the process of endochondral bone formation — that . . .