Anticonvulsant activity in photosensitive baboons, Papio papio, of two new 1,5 benzodiazepines
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 60 (3), 277-280
- https://doi.org/10.1007/bf00426668
Abstract
Two new 1,5 benzodiazepines have been evaluated acutely as anticonvulsants in baboons, Papio papio, with photosensitive epilepsy. BAU 426 (8-Chlor-6-[2-chlorphenyl]-4H-s-triazolo-[4,3-a] [1,5-benzodiazepin-5-[6-H]on) and BAU 500 (analogue of BAU 426 with [2-trifluor methylphenyl] substituted for [2-chlorphenyl]), 0.1–5.0 mg/kg, were administered i.v. to baboons with and without priming with D,l allylglycine. BAU 426 or BAU 500, 0.1–0.2 mg/kg, produced partial or transient protection against photically induced myoclonus or epileptic responses. Complete protection, in the absence of signs of sedation or acute neurological toxicity, was seen 1–4 h after 0.5–2 mg/kg. EEG changes typical of benzodiazepines were seen for 1–3 h and clinical signs of sedation with some muscular hypotonia were evident for 1 h after either drug, 5 mg/kg. Clinical trials are required to determine if these compounds are superior to 1,4 benzodiazepines as anticonvulsants.This publication has 9 references indexed in Scilit:
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