Six‐Month Effects of a Sanguinarine Dentifrice on Plaque and Gingivitis
- 1 April 1988
- journal article
- research article
- Published by Wiley in The Journal of Periodontology
- Vol. 59 (4), 238-243
- https://doi.org/10.1902/jop.1988.59.4.238
Abstract
A six-month, double-blind clinical trial was conducted to determine the effectiveness of a singuinarine-containing dentifrice in reducing plaque and gingival inflammation. One hundred twenty adult volunteers were randomly assigned to a control or experimental group. The test dentifrice contained 750 mcg/g of sanguinaria extract. A dentifrice of similar compostion without sanguinarine was used as the placebo. Plaque and gingival inflammation scores were recorded for four surfaces on each of 12 index teeth at baseline, one-, three, and six-months. Matched pair t-test analyses showed no significant differences between experimental and control groups for mean six-month changes in plaque and gingival inflammation scores in analyses using all 48 sites per subject or in analyses of only the 24 interproximal sites. No long-term reduction was demonstrated in plaque or gingival inflammation with the use of a sanguinarine-containing dentifrice.This publication has 9 references indexed in Scilit:
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