Conglobatin, a novel macrolide dilactone from Streptomyces conglobatus ATCC 31005.

Abstract

Fermentation of deposited cultures of S. conglobatus, which produces the polyether antibiotic ionomycin, resulted in the isolation and characterization of a 2nd metabolite, conglobatin (C28H38N2O6).X-ray analysis revealed a dimeric macrolide dilactone structure for conglobatin similar to the structures of the mold metabolites vermiculin and pyrenophorin, from which the absolute configuration of conglobatin was inferred. The dimer consists of 2 molecules of 7-hydroxy-8-oxazoyl-2,4,6-trimethyl-2-octenoic acid joined by 2 ester linkages.