The most important late complication of a longitudinal study of iris-supported lens was bullous keratopathy. Endothelial cell loss after using the closed chamber technique for lens insertion was more than halved. The cell loss rate after intracapsular extraction with a Federov I lens was compared with that after extracapsular extraction with an iridocapsular lens. The intermediate results did not show any significant difference between groups and there were eyes in both groups with a large initial loss which appeared to lose cells at a faster rate.