Modulation of the Metastatic Capability in B16 Melanoma by Cell Shape
- 23 September 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4617), 1307-1310
- https://doi.org/10.1126/science.6612347
Abstract
The lung colonization of B16-F1 cells grown in flat and spherical configurations was studied. Cells cultivated in vitro as spheroids on a nonadhesive substrate expressed in a reversible fashion a marked increase in their propensity to establish metastases. The altered metastatic capability was accompanied by a reversible reduction in the accessibility of cell surface proteins to external iodination and by a dramatic decrease in the synthesis of vimentin.This publication has 12 references indexed in Scilit:
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