High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
- 1 April 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 350 (6320), 678-683
- https://doi.org/10.1038/350678a0
Abstract
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.Keywords
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