HYPERSENSITIVITY PRODUCED BY THE TOPICAL APPLICATION OF SULFATHIAZOLE

Abstract

The use of sulfonamides locally has progressed rapidly during the last several years. In the treatment of various pyogenic infections of the skin sulfathiazole ointment has been described in several series of cases with satisfactory results and no toxic manifestations. Sams and Capland¹ had favorable results with sulfathiazole ointment in 53 cases of cutaneous infections with no detrimental local or systemic effects. Beinhauer, Knoll and Perrin² treated 19 patients with infectious eczematoid dermatitis, with 13 instances of clinical cure and 5 of decided improvement. Winer and Strakosch³ stress the value of sulfathiazole ointment in the treatment of impetigo contagiosa and even reported excellent results with only the oral use of the drug. The Robinsons⁴ reported excellent results with the local treatment of the dermatosis of 94 patients. Strakosch and Olsen⁵ stated that topical administration of sulfathiazole is advantageous because local tissue concentration will be reached