Application of the Intramolecular Vinylogous Morita−Baylis−Hillman Reaction toward the Synthesis of the Spinosyn A Tricyclic Nucleus
- 13 August 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (18), 3157-3160
- https://doi.org/10.1021/ol026540d
Abstract
[reaction: see text] A concise synthesis of the spinosyn A tricyclic nucleus 27 has been developed by a route featuring a one-pot tandem intramolecular Diels-Alder reaction and intramolecular vinylogous Morita-Baylis-Hillman cyclization in which five stereocenters in tricycle 10 are set with excellent selectivity.Keywords
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