Detection of Epstein‐Barr virus DNA in American Burkitt's lymphoma
- 15 June 1976
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 17 (6), 701-706
- https://doi.org/10.1002/ijc.2910170603
Abstract
Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein‐Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serorogical profiles similar to those of African patients with BL: one and possibly two of these patients harbored EBV‐DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV‐DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV‐associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.This publication has 23 references indexed in Scilit:
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