Functional and Structural Implications of Variable Region Immunoglobulin Dynamic States
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Immunological Investigations
- Vol. 17 (1), 25-39
- https://doi.org/10.3109/08820138809055716
Abstract
The consequence of multiple conformational states in the immunoglobulin variable region are considered. Bound ligand is viewed as a stabilizer of one conformer from a series of non-liganded conformers. Kinetic, equilibrium, thermodynamic and crystal formation information are used as supporting evidence for a unique conformer' which is the crystallizable liganded state. The multi-state model is discussed in terms of certain biological and biochemical properties exhibited by the immunoglobulin molecule.This publication has 33 references indexed in Scilit:
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