Vesicle fusion following receptor-mediated endocytosis requires a protein active in Golgi transport
- 1 June 1989
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 339 (6223), 398-400
- https://doi.org/10.1038/339398a0
Abstract
IN reconstitution studies N-ethylmaleimide, a sulphydryl alkylating reagent, inhibits both fusion of endocytic vesicles1–3 and vesicular transport in the Golgi apparatus4. We show here that the same N-ethylmaleimide-sensitive factor that catalyses the vesicle-mediated transport within Golgi stacks is also required for endocytic vesicle fusion. Thus, it is likely that a common mechanism for vesicle fusion exists for both the secretory and endocytic pathways of eukaryotic cells.Keywords
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