CHANGES IN RENAL FUNCTIONS ASSOCIATED WITH DIABETES INSIPIDUS PRECIPITATED BY ANTERIOR HYPOTHALAMIC LESIONS

Abstract

With the development of diabetes insipidus following the anatomical destruction of the neurohypophysis without damage to the adenohypophysis, glomerular filtration rate, renal plasma flow and the maximal rate of transfer of dextrose, all decrease 50% or more. These changes are proportional and are believed to be caused by the inactivation of nephrons with the development of diabetes insipidus. This may be an additional mechanism for conserving water, since it seems to operate in normal animals subjected to moderate dehydration.