G0 is a major growth cone protein subject to regulation by GAP-43
- 1 April 1990
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 344 (6269), 836-841
- https://doi.org/10.1038/344836a0
Abstract
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.Keywords
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