STUDIES ON TUBERCULIN FEVER
Open Access
- 1 April 1959
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 109 (4), 339-359
- https://doi.org/10.1084/jem.109.4.339
Abstract
Evidence has been presented that the fever elicited by intravenous administration of old tuberculin (O.T.) in BCG-infected rabbits is a specific property of this hypersensitivity system and is probably not due to contamination of tuberculin with bacterial endotoxins. Daily injections of O.T. in sensitized animals resulted in a rapid tolerance to its pyrogenic effect. Tuberculin tolerance can be differentiated from that occurring with endotoxins and was invariably associated with the development of a negative skin test. The mechanism of this tolerance would thus appear to be desensitization.Keywords
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